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Senior Research Associate

Posted 25 days ago

  • Expiry Date: 22 May 2022

Job Description:

  • The candidate will work with our translational development team and independently contribute to the development and execution of laboratory experiments to understand disease biology, drug resistance, mechanism of action of drugs and drug combinations.

  • This will include working with multiple myeloma cell lines, immune cell lines and cells derived from healthy donors and multiple myeloma patients.

  • The candidate should have enthusiasm for helping support laboratory programs, have knowledge of immunology, cell biology and signal transduction pathways and technical expertise in flow cytometry and molecular based assays documented by relevant publications and work experience.

  • They should also possess a strong understanding of the science behind ongoing experiments: the rationale, purpose and appropriate analytical methods to aid experimental design, troubleshooting and result interpretation.

Requirements:

  • A Bachelors degree in the Life Sciences with 5+ years of hands-on research experience or Masters degree with 2+ years experience, or a PhD in biological sciences from a research environment

  • Experience with multi-parameter flow cytometry, tissue culture and working with PBMCs a must.

  • Prior experience in immunology is a big plus

  • Proficient with general skills of molecular cell biology, such as RNA isolation, RT-PCR, Western Blotting, ELISA/Luminex, and basic cellular assays (e.g. proliferation/apoptosis).

  • Experience in isolating Monocytes, T-cells and NK cells from PBMCs a plus.

  • Experience in immunophenotyping is a plus.

  • Experience with PowerPoint, FlowJo and GraphPad Prism software.

  • Communication and writing skills necessary to effectively convey data and interpretations with internal groups and at external meetings.

  • Problem solving skills to resolve technical issues.

  • Ability to manage time efficiently to meet project team deadlines and exhibit flexibility and adaptability to changing projects, work assignments and priorities.

Responsibilities:

  • The candidate will provide laboratory support by means of data generation and analysis for clinical trial biomarker strategies, publications and internal study reports.

  • Performing in vitro and ex vivo testing of compounds and monoclonal antibodies on immune cells and tumor cells to evaluate mechanisms of drug response and resistance, to identify

  • pharmacodynamic markers and to develop rational drug combination strategies.

  • Performing in vitro co-culture assays with immune cells and tumor cells to assess drug effects.

  • Performing molecular and cell biological techniques including, flow cytometry analysis, RNA preparation qRT-PCR analysis, western blot, proliferation and apoptosis assays.

  • Participating in translational team meetings by presenting data and providing interpretation of experimental results.

  • Helping to cultivate a positive and productive working relationship with colleagues.

About ASK: ASK Consulting is an award-winning technology and professional services recruiting firm servicing Fortune 500 organizations nationally. With 5 nationwide offices, two global delivery centers, and employees in 42 states-ASK Consulting connects people with amazing opportunities.

ASK Consulting is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all associates.