- Expiry Date: 01 August 2021
The Sr. Associate Scientist will join in the Translational Development team in Oncogenesis Thematic Research Center (TRC) located in San Diego, California. The successful candidate will have a broad understanding of molecular cell biology, immunology, and oncology, with strong expertise in cell-based assay development and biomarker discovery.
The incumbent will be responsible for addressing questions of drug scheduling, supporting patient selection hypothesis and developing clinical assays using current techniques and primarily in vitro and ex vivo methods; and is responsible for experiment design, execution, and data analysis and report for well-defined projects. The position will require handling and compound treatment of human tissues including whole blood, PBMC, bone marrow aspirates, tumor cell lines and primary tumors. The incumbent will be expected to maintain an electronic lab notebook and organize results into reports or presentations. The ideal candidate will possess strong communication, writing and record keeping, and presentation skills. The successful candidate will have a proven technical and scientific track record and experience working in a multi-disciplinary team environment.
Responsibilities will include, but are not limited to, the following
Independently execute defined experiments, data analysis and data QC
Design and conduct relevant molecular and cell-based assays to support MOA research and translational development
Analyze and present data in an organized and timely manner
Rigorous review of data and help plan next steps.
Handling and processing human bio specimens
Collaborate effectively and cultivate positive and productive relationships with colleagues
Participate in maintenance of routine laboratory instrumentation and supplies
Adherence to laboratory safety policies and practices.
Bachelor’s degree in a scientific discipline with at least 8 years industry experience or Master’s degree with at least 6 years of industry experience in oncology research
Demonstrated proficiency in various molecular and cellular technologies including, but not limited to, sterile cell culture, cell-based assays (CTG, apoptosis) and molecular biology techniques (Protein, DNA and RNA isolations, Western blot, ELISA, qRT-PCR)
Proficiency with multi-color flow cytometry techniques and analysis
Possess trouble shooting and problem-solving skills to resolve technical questions in a multi-disciplinary environment
Experience with high-throughput drug screening is a plus
Skilled in Microsoft Office Suite, GraphPad Prism, FlowJo
Excellent communication, collaboration and organizational skills and attention to detail
Ability to work in a fast-paced environment; flexibility to adapt to changes with a positive attitude
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