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Research Scientist

Posted 23 days ago

  • Expiry Date: 04 December 2022
  • Referral: 219373@accuick.com

Job Description:

  • Bachelors or higher degree in a scientific discipline with 1-3 years of work experience.

  • Experience preferred in industry or drug discovery setting.

Summary/Scope

  • The Molecular and Cellular Pharmacology Group in Oncology TRC focuses on delivering novel cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation.

  • We are seeking a motivated Associate Scientist with experience in drug discovery and in vitro pharmacology to participate in research focused on protein homeostasis for cancer therapeutics.

  • The successful candidate will work collaboratively in a multi-disciplinary environment to use cell-based assays in support of discovery of small molecules as development candidates (DCs) for clinical, design and execute in vitro studies to further our understanding of the mechanisms of novel compounds.

  • Oncology TRC

  • The Oncology TRC is one of the fundamental research and early development engines delivering therapeutics to patients.

  • The group integrates discovery research through translational and early clinical development and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system, protein translation, and RNA processing and stability.

  • This thematic focus allows the group to capitalize on the cutting edge science that underpins the action of the company's most advanced drugs.

  • Not being bound by disease area or therapeutic modality creates a very dynamic, exciting and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology and translational development.

Responsibilities will include but are not limited to the following:

  • Develop and implement relevant cell-based and biochemical assays as well as cell models to support identification, optimization, and characterization of novel chemical matter.

  • Design and conduct critical experiments using expertise in cell biology, molecular biology, biochemistry and assay development to support molecular mechanism of action of the drugs.

  • Analyze and present data in an organized and timely manner.

  • Support biology needs for different projects and drug discovery teams.

Requirements:

  • Experience in various molecular biology techniques (DNA cloning, Western blot, PCR, qPCR).

  • Experience in cell biology including mammalian cell culture, lentivirus production, transient/stable transfection.

  • Experience in gene editing including CRISPR, KO and -KI, or shRNA Knockdown is plus.

  • Experience in small molecule drug discovery process in an industrial setting is preferred.

  • Familiarity and willingness to learn in vitro cell-based assays, including but not limited to: cell proliferation assays, cell cycle assay, apoptosis assay, bDNA assay, image-based assays, ELISA, and Incucyte.

  • Familiar with various biology laboratory equipment with an emphasis on automation and capable of trouble shooting for SAR assay support.

  • Excellent communication, collaboration, and organizational skills.

  • Capability to stay focused, multitasked, attention to details and deliver high quality data in a timely and well-organized manner.

  • Ability to handle multiple projects and work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude.

About ASK: ASK Consulting is an award-winning technology and professional services recruiting firm servicing Fortune 500 organizations nationally. With 5 nationwide offices, two global delivery centers, and employees in 42 states-ASK Consulting connects people with amazing opportunities

ASK Consulting is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all associates.

Contact:

Full Name: Akash Mehra

Email ID: akashm@askconsulting.com

Phone: 908-224-9613