- Expiry Date: 25 May 2022
- Referral: email@example.com
The Research Scientist will join the Early Drug Discovery group in Cambridge, MA and aide in the advancement of early-stage therapeutic targets.
The position will utilize genome engineering, mechanistic biology, assay development, and other cutting-edge technologies to validate tumor intrinsic targets and support drug discovery pipeline.
The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment and aid the advancement of the next wave of targets into preclinical drug development.
The candidate will be expected to effectively collaborate with colleagues across discovery oncology including the exploratory pharmacology, drug discovery and translational research groups.
The position requires the ability to design, iterate, and lead several key project initiatives and demonstrate critical thinking to challenge self and others.
The successful candidate will demonstrate clear and professional verbal and written communication skills and will be capable of communicating these results across multidisciplinary teams.
Qualifications and key responsibilities
A B.S. with a minimum of 4 - 7 years, an M.S. with a minimum of 3 - 5 years, or a PhD with a minimum of 2 - 3 years of academic/industrial experience and demonstrated expertise in cancer biology and genetics, oncogenic signaling or DNA damage response pathways.
Demonstrated independence in experimental design, execution, data analysis, and troubleshooting are required.
Strong scientific and hands-on experience using a wide range of cellular and molecular biology techniques, including tissue culture, flow cytometry, western blotting, Immunoprecipitation, development of reporter assays, MSD, ELISA, use of genetic perturbation techniques (eg shRNA,siRNA CRISPR-mediated genome editing), qRT-PCR, cell proliferation assays, lentivirus generation and transduction are required.
Experience in forward and reverse genetic screening followed by target validation studies to elucidate mechanistic biology and oncogenic SAR is strongly preferred.
Proficiency in utilizing software such as Graph Pad, FlowJo, Microsoft office etc. for data analysis and figure generation is required.
Ability to lead, design, and execute on project initiatives and operates to a High Standard. Attention to detail with excellent organizational and record keeping skills is a requirement.
Excellent interpersonal skills with the ability to interact effectively with people, internally and externally, is required.
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