- Expiry Date: 16 August 2021
We are seeking an Associate Research Scientist with a strong interest in protein expression and bioprocess development to join the protein science group in the Discovery Biotherapeutics department at our new state-of-the art facility in San Diego, CA. The qualified candidate will be responsible for mammalian protein expression and bioprocess development in both shake flasks and automated mini-bioreactors, and other lab related activities as assigned.
Responsibilities will include, but are not limited to, the following:
Expression of antibodies (bi-/multi-specific antibodies) and other recombinant proteins in transient and stable formats to support biotherapeutic drug discovery projects.
Mammalian cell culturing in both shake flasks and automated mini-bioreactors, along with HT automated liquid handling systems.
Process development and optimization for batch and fed-batch bioreactor and shake flask expressions.
Transient protein expression as well as stable pool and single cell cloning generation.
Purification and biophysical characterization of analytical scale expression samples.
Ensure accurate registration of protein expression samples and associated data into electronic inventory system and electronic laboratory notebook.
Candidate should have a B.S or M.S in Biology, Biochemistry, Bioengineering or a related field with at least 2-4 years of relevant experience in an industry setting.
Hands on experience with mammalian cell (CHO, HEK) culture, transient and stable transfection and protein characterization.
Experience with operating Ambr mini-bioreactor and bench scale bioreactor, HT automation and analysis, bioprocess development and process optimization is highly desirable.
Proficiency with Design of experiment (DOE) and DOE analysis software will be a plus.
Working knowledge and familiar with protein and antibody purification and analytical assessment.
Excellent data management skills and a demonstrated ability to manage large structure datasets using
Excellent written and oral communication skills including ability to present scientific data in group setting.
Excellent organization to multi-task and manage multiple projects.
Implement and validate protocols.
Mastery of basic lab skills.
Reviewing literature for technical support.
Familiarity with data retrieval and input from database.
Tasks and Responsibilities:
With assistance, executes experiments, conducts analysis and reports results.
Familiarity with work and business practices to be able to identify and troubleshoot routine problems.
Requires less direction to complete assigned tasks.
Consults colleagues for advice on issues.
Creativity and Problem Solving:
Recognize unexpected outcome/problems; communicates and works with supervisor to solve.
Learn from the past experience to improve the current process.
Teamwork and Influence:
Communicates with peers and supervisors.
Begin to communicate with departments and customers.
Works in context of immediate work group or team.
Has a direct impact on workgroup performance.
Impact is achieved by contributing to workgroup.
Commitment to quality Demonstrates adaptability
Develops oneself Drive for results
Effective speaking Fosters teamwork
Listens to others Prepares written communications
Shows work commitment Uses functional/technical expertise
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ASK Consulting is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all associates.